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From left, Shikha Chaganti, Anca Ralescu and Gaurav Mukherjee work on a brain-computer interface project. Credit: University of Cincinnati

If you think with the release of every new i-device the world is getting closer to thought-controlled smart tech and robotic personal assistants, you might be right. And thanks in part to work led by the University of Cincinnati's Anca Ralescu, we may be even closer than you realize. Professor Ralescu of the Department of Electrical Engineering and Computing Systems will discuss her team's research aims and current progress on brain-computer interface at theInternational Human-Centered Robotics Symposium (HuCeRo). The University of Cincinnati’s College of Engineering and Applied Science (CEAS) will host the symposium on Nov. 14-17 at UC’s Kingsgate Marriott Conference Center. The symposium aims to bring together leading researchers and engineers in the fields of robotics, computer science, material science and brain-computer interaction. Ralescu's presentation will be Nov. 17. Brain-computer interface uses electroencephalography (a measure of the brain's electrical activity) to help distinguish which brain signal corresponds with the body's performance of a particular intended action. In these experiments, Shikha Chaganti, a graduate student in computer science advised by Ralescu, specifically targeted brain impulses generated when a person thought about going from a sitting position to standing and vice versa. Computers process this data – which can be reinforced by combining it with measures of electrical activity in muscle – in order to detect these brain signals and interpret their intent. The idea is to allow a

Credit: University of Cincinnati/ Anca Ralescu

person to use thought alone to communicate with a computer about the intent to move. "The problem is quite difficult," Ralescu says. "We are experimenting with processing the signal and selecting useful features from it, and designing a classifier capable of distinguishing between the these two transitions – sitting to standing and standing to sitting." From left, Shikha Chaganti, Anca Ralescu and Gaurav Mukherjee use brain-computer interface to distinguish which brain signal corresponds with the body's performance of a particular intended action. credit: University of Cincinnati Ralescu's work eventually could be used in conjunction with another project being presented at HuCeRo by UC's Gaurav Mukherjee, a master’s student in mechanical engineering in UC’s College of Engineering and Applied Science (CEAS), and Grant Schaffner, an assistant professor in UC’s Department of Aerospace Engineering and Engineering Mechanics. Mukherjee and Schaffner designed and built a spring-assisted leg exoskeleton that can help people with impaired mobility. By integrating Ralescu's brain-computer interface into the exoskeleton, someone using the device could think, "I'm going to stand," and they'd receive a robotic boost as they rose to their feet. Ralescu also says HuCeRo will feature discussion of UC's development of an interdisciplinary curriculum for human-centered robotics. "The idea of human-centered systems in general, and human-centered robotics in particular, is not new. But to some extent things were just not in place. Some technology or other was either missing or too expensive," Ralescu says. "To my knowledge, there is no formal curriculum in this area in any university. If UC moves forward with creating such a curriculum, it could be among the first of its kind. So UC would be a pioneer in establishing such a curriculum." In addition to the contributions from UC graduate students Chaganti and Mukherjee, Ralescu’s work has benefited from interaction with Jonathan Adam Wilson, a postdoctoral fellow in pediatrics at UC and of Cincinnati Children's Hospital Medical Center; Tomasz Rutkowski of the University of Tsukuba and the Brain Science Institute at RIKEN in Japan; and Christoph Guger, CEO of Guger Technologies in Graz, Austria. Ralescu, Schaffner, Wilson and Manish Kumar (formerly associate professor of mechanical engineering in UC’s College of Engineering and Applied Science and currently at the University of Toledo) are preparing a proposal for the National Science Foundation's National Robotics Initiative in collaboration with UC's Department of Neurosurgery and the Daniel Drake Center. The symposium is funded by a grant from the University of Cincinnati Faculty Development Council to Ralescu and Schaffner, and is further supported by the College of Engineering and Applied Science. Contacts and sources: Tom Robinette University of Cincinnati. Source: Nano Patents And Innovations

Read More........→November 14, 2013 Categories: Brain,Robot,Science-Technology,University

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The U.S. Food and Drug Administration (FDA) granted market approval to an artificial retina technology today, the first bionic eye to be approved for patients in the United States. The prosthetic technology was developed in part with support from the National Science Foundation (NSF). The device, called the Argus® II Retinal Prosthesis System, transmits images from a small, eye-glass-mounted camera wirelessly to a microelectrode array implanted on a patient's damaged retina. The array sends electrical signals via the optic nerve, and the brain interprets a visual image. While the Argus II is a major breakthrough in retinal prosthetics, researchers are continuing their research. This third-generation retina chip, itself still very early in the development stage, contains 1,000 electrodes and was developed by Wentai Liu, a professor of bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science and his colleagues. Early engineering done by Liu and his team was licensed to Second Sight

for the Argus II Retinal Prosthesis System. The FDA approval currently applies to individuals who have lost sight as a result of severe to profoundretinitis pigmentosa (RP), an ailment that affects one in every 4,000 Americans. The implant allows some individuals with RP, who are completely blind, to locate objects, detect movement, improve orientation and mobility skills and discern shapes such as large letters.The Argus II is manufactured by, and will be distributed by, Second Sight Medical Products of Sylmar, Calif., which is part of the team of scientists and engineers from the university, federal and private

Credit: Wentai Liu, UCLA

sectors who spent nearly two decades developing the system with public and private investment. "Seeing my grandmother go blind motivated me to pursue ophthalmology and biomedical engineering to develop a treatment for patients for whom there was no foreseeable cure," says the technology's co-developer, Mark Humayun, associate director of research at the Doheny Eye Institute at the University of Southern California and director of the NSF Engineering Research Center for Biomimetic MicroElectronic Systems(BMES). "It was an interdisciplinary approach grounded in biomedical engineering that has allowed us to develop the Argus II, making it the first commercially approved retinal implant in the world to

restore sight to some blind patients," Humayun adds. The effort by Humayun and his colleagues has received early and continuing support from NSF, the National Institutes of Health and the Department of Energy, with grants totaling more than $100 million. The private sector's support nearly matched that of the federal government. "The retinal implant exemplifies how NSF grants for high-risk, fundamental research can directly result in ground-breaking technologies decades later," said Acting NSF Assistant Director for Engineering Kesh Narayanan. "In collaboration with the Second Sight team and the courageous patients who volunteered to have experimental surgery to implant the first-generation devices, the researchers of NSF's Biomimetic MicroElectronic Systems Engineering Research Center are developing technologies that may ultimately have as profound an impact on blindness as the cochlear implant has had for hearing loss." Although some treatments to slow the progression of degenerative diseases of the retina are available, no treatment has existed that could replace the function of lost photoreceptors in the eye. The researchers began their retinal prosthesis research in the late 1980s to address that need, and in 1994 Humayun received his first NSF grant, an NSF Young Investigator Award, which built upon additional support from the Whittaker Foundation. Humayun used the funding to develop the first conceptualization of the Argus II's underlying artificial retina technology. Since that time, he and his collaborators--including Wentai Liu of the University of California, Los Angeles and fellow USC researchers Jim Weiland and Eugene de Juan, Jr.--received six additional NSF grants, totaling $40 million, some of which was part of NSF's funding for BMES, launched in 2003. BMES drives research into a range of sophisticated prosthetic technologies to treat blindness, paralysis and other conditions. "We were encouraged by the team's exploratory work in the 1980s and 1990s, supported by NSF and others, which revealed that healthy neural pathways can carry information to the brain, even though other parts of the eye are damaged," adds Narayanan. "The retinal prosthesis they developed from that work simulates the most complex part of the eye. Based on the promise of that implant, we decided in 2003 to entrust the research team with an NSF Engineering Research Center," says Narayanan. "The center was to scale up technology development and increase device sensitivity and biocompatibility, while simultaneously preparing students for the workforce and building partnerships to speed the technology to the marketplace, where it could make a difference in people's lives. The center has succeeded with all of those goals." The researchers' efforts have bridged cellular biology--necessary for understanding how to stimulate the retinal ganglion cells without permanent damage--with microelectronics, which led to the miniaturized, low-power integrated chip for performing signal conversion, conditioning and stimulation functions. The hardware was paired with software processing and tuning algorithms that convert visual imagery to stimulation signals, and the entire system had to be incorporated within hermetically sealed packaging that allowed the electronics to operate in the vitreous fluid of the eye indefinitely. Finally, the research team had to develop new surgical techniques in order to integrate the device with the body, ensuring accurate placement of the stimulation electrodes on the retina. "The artificial retina is a great engineering challenge under the interdisciplinary constraint of biology, enabling technology, regulatory compliance, as well as sophisticated design science," adds Liu. "The artificial retina provides an interface between biotic and abiotic systems. Its unique design characteristics rely on system-level optimization, rather than the more common practice of component optimization, to achieve miniaturization and integration. Using the most advanced semiconductor technology, the engine for the artificial retina is a 'system on a chip' of mixed voltages and mixed analog-digital design, which provides self-contained power and data management and other functionality. This design for the artificial retina facilitates both surgical procedures and regulatory compliance." The Argus II design consists of an external video camera system matched to the implanted retinal stimulator, which contains a microelectrode array that spans 20 degrees of visual field. The NSF BMES ERC has developed a prototype system with an array of more than 15 times as many electrodes and an ultra-miniature video camera that can be implanted in the eye. However, this prototype is many years away from being available for patient use. "The external camera system-built into a pair of glasses-streams video to a belt-worn computer, which converts the video into stimulus commands for the implant," says Weiland. "The belt-worn computer encodes the commands into a wireless signal that is transmitted to the implant, which has the necessary electronics to receive and decode both wireless power and data. Based on those data, the implant stimulates the retina with small electrical pulses. The electronics are hermetically packaged and the electrical stimulus is delivered to the retina via a microelectrode array." In 1998, Robert Greenberg founded Second Sight to develop the technology for the marketplace. While under development, the Argus I and Argus II systems have won wide recognition, including a 2010 Popular Mechanics Breakthrough Award and a 2009 R&D 100 Award, but it is only with FDA approval that the technology can now be made available to patients. "An artificial retina can offer hope to those with retinitis pigmentosa, as it may help them achieve a level of visual perception that enhances their quality of life, enabling them to perform functions of daily living more easily and the chance to enjoy simple pleasures we may take for granted," says Narayanan. "Such success is the result of fundamental studies in several fields, technology improvements based on those results and feedback from clinical trials--all enabled by sustained public and private investment from entities like NSF." Contacts and sources: National Science Foundation, Source: Nano Patents And Innovation