Indian American scientist hoping to be first woman to jump from stratosphere

Swati Varshey has a PhD in materials science from the Massachusetts Institute of Technology and has made over 1,200 jumps with a speciality in vertical freefall, according to Space.com. Swati Varshney. PHOTO: @risingunited.org An Indian-American scientist is hoping to become the first woman to skydive from the stratosphere at an altitude of 42.5 km above the Earth, and shatter four records in the process. Swati Varshey has been selected as one of the three candidates selected by the Hera Project of Rising United that seeks to empower women in science and technology, the organization has announced. - If she makes it to the skydive in 2025, Hera Project expects her to break four current records: The free fall record by 1.1 kilometer from the highest altitude; endure the longest free fall time; break the sound barrier unaided by 264 kph; and the highest crewed balloon flight by over 1 kilometer. “At Rising United, we’re embarking on a historic journey, shattering records and ceilings to advance women’s equality and inspire young women’s interest in STEAM education”, the organization said. Swati Varshey has a PhD in materials science from the Massachusetts Institute of Technology and has made over 1,200 jumps with a specialty in vertical freefall, according to Space.com. Billed as the “First Female Mission to the Edge of Space”, the project seeks to have minority women smash the records, and the other two contenders are of Latino descent, Eliana Rodriquez and Diana ValerĂ­n JimĂ©nez. The project will include educational programs for schools to increase interest in science and technology among girls, especially from minority groups. Varshney told Space.com that for her skydiving “is a lot more similar to my scientific training than I ever thought it would have been in the first place. It was just another avenue for me to pursue this goal of lifelong learning”. Varshney, who has spent a decade skydiving, told the media outlet, “My academic progression and my career trajectory has been really intertwined with skydiving as it went along. So I started skydiving”. She tried tandem jumping and found it such a “blast”, that she took it up as a hobby. “ I really just wanted something that was totally different, and as a release to — this is a really clichĂ© way to say it — cut away right from what I was doing in my day-to-day life”, she told Space.com. “It became this never-ending journey of another pursuit of knowledge that went alongside my academic career”, she added. The stratosphere is from about 6 kilometers to 50 kilometers above the earth where it gives way to the mesosphere. Indian American scientist hoping to be first woman to jump from stratosphere:
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Aerial Undulation’s Role In Flying Snake Glides Revealed

The paradise tree snake mid-glide. Photo by Jake Socha.
When the paradise tree snake flies from one tall branch to another, its body ripples with waves like green cursive on a blank pad of blue sky. That movement, aerial undulation, happens in each glide made by members of the Chrysopelea family, the only known limbless vertebrates capable of flight. Scientists have known this, but have yet to fully explain it.

For more than 20 years, Jake Socha, a professor in the Department of Biomedical Engineering and Mechanics, has sought to measure and model the biomechanics of snake flight and answer questions about them, like that of aerial undulation’s functional role. For a study published by Nature Physics, Socha assembled an interdisciplinary team to develop the first continuous, anatomically-accurate 3D mathematical model of Chrysopelea paradisi in flight.

The team, which included Shane Ross, a professor in the Kevin T. Crofton Department of Aerospace and Ocean Engineering, and Isaac Yeaton, a recent mechanical engineering doctoral graduate and the paper’s lead author, developed the 3D model after measuring more than 100 live snake glides. The model factors in frequencies of undulating waves, their direction, forces acting on the body, and mass distribution. With it, the researchers have run virtual experiments to investigate aerial undulation.

In one set of those experiments, to learn why undulation is a part of each glide, they simulated what would happen if it wasn’t — by turning it off. When their virtual flying snake could no longer aerially undulate, its body began to tumble. The test, paired with simulated glides that kept the waves of undulation going, confirmed the team’s hypothesis: aerial undulation enhances rotational stability in flying snakes.



The paradise tree snake is a member of the Chrysopelea family, the only know limbless vertebrates capable of flight., Photo by Jake Socha.

Questions of flight and movement fill Socha’s lab. The group has fit their work on flying snakes between studies of how frogs leap from water and skitter across it, how blood flows through insects, and how ducks land on ponds. In part, it was important to Socha to probe undulation’s functional role in snake glides because it would be easy to assume that it didn’t really have one.

“We know that snakes undulate for all kinds of reasons and in all kinds of locomotor contexts,” said Socha. “That’s their basal program. By program, I mean their neural, muscular program⁠ — they’re receiving specific instructions: fire this muscle now, fire that muscle, fire this muscle. It’s ancient. It goes beyond snakes. That pattern of creating undulations is an old one. It’s quite possible that a snake gets into the air, then it goes, 'What do I do? I’m a snake. I undulate.'”

But Socha believed there was much more to it. Throughout the paradise tree snake’s flight, so many things happen at once, it’s difficult to untangle them with the naked eye. Socha described a few steps that take place with each glide ⁠— steps that read as intentional.

First, the snake jumps, usually by curving its body into a “J-loop” and springing up and out. As it launches, the snake reconfigures its shape, its muscles shifting to flatten its body out everywhere but the tail. The body becomes a “morphing wing” that produces lift and drag forces when air flows over it, as it accelerates downward under gravity. Socha has examined these aerodynamic properties in multiple studies. With the flattening comes undulation, as the snake sends waves down its body.

At the outset of the study, Socha had a theory for aerial undulation he explained by comparing two types of aircraft: jumbo jets versus fighter jets. Jumbo jets are designed for stability and start to level back out on their own when perturbed, he said, whereas fighters roll out of control.

So which would the snake be?

“Is it like a big jumbo jet, or is it naturally unstable?” Socha said. “Is this undulation potentially a way of it dealing with stability?”

He believed the snake would be more like a fighter jet.

To run tests investigating undulation’s importance to stability, the team set out to develop a 3D mathematical model that could produce simulated glides. But first, they needed to measure and analyze what real snakes do when gliding.

In 2015, the researchers collected motion capture data from 131 live glides made by paradise tree snakes. They turned The Cube, a four-story black-box theater at the Moss Arts Center, into an indoor glide arena and used its 23 high-speed cameras to capture the snakes’ motion as they jumped from 27 feet up — from an oak tree branch atop a scissor lift — and glided down to an artificial tree below, or onto the surrounding soft foam padding the team set out in sheets to cushion their landings.

The cameras put out infrared light, so the snakes were marked with infrared-reflective tape on 11 to 17 points along their bodies, allowing the motion capture system to detect their changing position over time. Finding the number of measurement points has been key to the study; in past experiments, Socha marked the snake at three points, then five, but those numbers didn’t provide enough information. The data from fewer video points only provided a coarse understanding, making for choppy and low-fidelity undulation in the resulting models.

The team found a sweet spot in 11 to 17 points, which gave high-resolution data. “With this number, we could get a smooth representation of the snake, and an accurate one,” said Socha.


 
The snakes wore 11 to 17 infrared-reflective markers, which gave the team high-resolution data while still allowing the animals to move freely., Photo by Jake Socha.

The researchers went on to build the 3D model by digitizing and reproducing the snake’s motion while folding in measurements they had previously collected on mass distribution and aerodynamics. An expert in dynamic modeling, Ross guided Yeaton’s work on a continuous model by drawing inspiration from work in spacecraft motion.

He had worked with Socha to model flying snakes since 2013, and their previous models treated the snake’s body in parts — first in three parts, as a trunk, a middle, and an end, and then as a bunch of links. “This is the first one that’s continuous,” said Ross. “It’s like a ribbon. It’s the most realistic to this point.”

In virtual experiments, the model showed that aerial undulation not only kept the snake from tipping over during glides, but it increased the horizontal and vertical distances traveled.

Ross sees an analogy for the snake’s undulation in a frisbee’s spin: the reciprocating motion increases rotational stability and results in a better glide. By undulating, he said, the snake is able to balance out the lift and drag forces its flattened body produces, rather than being overwhelmed by them and toppling, and it’s able to go further.

The experiments also revealed to the team details they hadn’t previously been able to visualize. They saw that the snake employed two waves when undulating: a large-amplitude horizontal wave and a newly discovered, smaller-amplitude vertical wave. The waves went side to side and up and down at the same time, and the data showed that the vertical wave went at twice the rate of the horizontal one. “This is really, really freaky,” said Socha. These double waves have only been discovered in one other snake, a sidewinder, but its waves go at the same frequency.

“What really makes this study powerful is that we were able to dramatically advance both our understanding of glide kinematics and our ability to model the system,” said Yeaton. “Snake flight is complicated, and it’s often tricky to get the snakes to cooperate. And there are many intricacies to make the computational model accurate. But it’s satisfying to put all of the pieces together.”

“In all these years, I think I’ve seen close to a thousand glides,” said Socha. “It’s still amazing to see every time. Seeing it in person, there’s something a little different about it. It’s shocking still. What exactly is this animal doing? Being able to answer the questions I’ve had since I was a graduate student, many, many years later, is incredibly satisfying.”

Jzake Socha positions a paradise tree snake on a branch during motion experiments in The Cube at the Moss Arts Center., Photo by Michael Diersing.


Socha credits some of the elements that shaped the real and simulated glide experiments to forces out of his control. Chance led him to the indoor glide arena: a few years after the Moss Arts Center opened, Tanner Upthegrove, a media engineer for the Institute for Creativity, Arts, and Technology, or ICAT, asked him if he’d ever thought about working in the Cube.

“What’s the Cube?” he asked. When Upthegrove showed him the space, he was floored. It seemed designed for Socha’s experiments.

In some ways, it was. “Many projects at ICAT used the advanced technology of the Cube, a studio unlike any other in the world, to reveal that which could normally not be seen,” said Ben Knapp, the founding director of ICAT. “Scientists, engineers, artists, and designers join forces here to build, create, and innovate new ways to approach the world’s grandest challenges.”

In one of the center’s featured projects, “Body, Full of Time,” media and visual artists used the space to motion capture the body movements of dancers for an immersive performance. Trading dancers for snakes, Socha was able to make the most of the Cube’s motion capture system. The team could move cameras around, optimizing their position for the snake’s path. They took advantage of latticework at the top of the space to position two cameras pointing down, providing an overhead view of the snake, which they’d never been able to do before.



The Cube is home to a 23-camera motion capture system., Photo by Jake Socha.

Socha and Ross see potential for their 3D model to continue exploring snake flight. The team is planning outdoor experiments to gather motion data from longer glides. And one day, they hope to cross the boundaries of biological reality.

Right now, their virtual flying snake always glides down, like the real animal. But what if they could get it to move so that it would actually start to go up? To really fly? That ability could potentially be built into the algorithms of robotic snakes, which have exciting applications in search and rescue and disaster monitoring, Ross said.

“Snakes are just so good at moving through complex environments,” said Ross. “If you could add this new modality, it would work not only in a natural setting, but in an urban environment.”

“In some ways, Virginia Tech is a hub for bio-inspired engineering,” said Socha. “Studies like this one not only provide insight into how nature works, but lay the groundwork for design inspired by nature. Evolution is the ultimate creative tinkerer, and we’re excited to continue to discover nature’s solutions to problems like this one, extracting flight from a wiggling cylinder.”
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Blood work: scientists uncover surprising new tools to rejuvenate the brain


Scientists used to believe that our neurologic fate was sealed at birth with a single, lifetime allotment of brain cells.The thinking went – not so very long ago – that little by little, with the bumps of age and lifestyle, this initial stash of neurons died, taking our brain function along with them. Yet, strange as it may sound, canaries, video games, and young blood are finally putting that punishing prospect to rest . Studies involving bird song, gaming, and the rejuvenating factors of young blood have shown not only that neurons can be generated throughout adulthood, but also that the maddening aspects of ageing, such as memory loss and slower processing speed, can be partially reversed. Both neuro-scientists and
Illustration by David Senior
coal miners revere the canary, but for entirely different reasons. Like humans, canaries are known in neuro-science as ''open learners,'' meaning they learn throughout adulthood. ''Canaries learn songs, like we learn language, from older adults when young,'' explains Arturo Alvarez-Buylla, PhD, a stem cell neurobiologist at UC San Francisco. As they get older, they tweak their songs seasonally to distinguish themselves during mating season. Alvarez-Buylla's mentor, neuroscientist Fernando Nottebohm, PhD, a professor at Rockefeller University, suspected that as these parts of the canary brain assembled and disassembled for the yearly acquisition of the new mating song, new neurons were being taken on board. Such a notion was unimaginable at the time. ''When Nottebohm proved by morphology, electrophysiology, electron micro-scopy, and connectivity between 1983 and 1986 that the new cells were neurons, the whole field of stem cell science became a lot more exciting,'' recalls Alvarez-Buylla, who holds the Heather and Melanie Muss Endowed Chair in the Department of Neurological Surgery. The jaws of neuroscientists throughout the world dropped at the possibilities posed by Nottebohm's finding. Neurogenesis offered a new way to repair damage wrought by age, neurological injury, or disease. Alvarez-Buylla went on to advance the field ever further by identifying the neural stem cell, its origins, and its behavior in the mammalian brain.Blood shot: 
Now, decades later, young blood – literally speaking – has joined the canary as a harbinger and waypoint en route to realizing the promise of neurologic rejuvenation. Last spring, University of California at San francisco (UCSF) Faculty Fellow Saul Villeda, PhD, published a study in Nature Medicine showing significant signs of reversal of age-related cognitive decline in old mice after they were infused with the blood of young mice over the course of several weeks. Two other studies showing the revitalizing effects of young blood in brain and muscle tissue were published at the same time. ''All three studies coming out simultaneously made things go supernova,'' says Villeda, who, at the age of 33, is a bit of a young blood himself. In the media frenzy that followed, Villeda was inundated with requests for interviews, in both English and Spanish. Born and raised in East Los Angeles, Villeda was able to deliver in both languages. ''What we were saying collectively, across three impressive institutions – UCSF, Stanford, and Harvard – is that there is reversibility in the ageing process. It's a bit of a game changer.'' The experiment itself proved quite easy for Villeda to explain to the lay press. He and the graduate students in his lab took the blood of young mice, stripped it of its cells, and infused the remaining plasma into old mice. They did this every three days for 24 days, using small injections of the plasma each time – just 5 per cent of a mouse's blood volume. The young mice in the study were 3 months old, the equivalent of humans in their 20s, and the old mice were 18 months old, the equivalent of humans in their 60s. Days later, he tested them for cognitive changes. In one experiment, the mice had to wind through a water maze and remember where a dry platform was hidden; in another, the mice had to recall a location where they had received a shock. ''When we gave them the injections of young blood, they no longer had the cognitive impairments of a normally ageing mouse,'' says Villeda. ''Their performance wasn't quite equal to the young mice, but pretty close.'' The two experiments tested the functioning of the hippocampus, a part of the brain, in both mice and humans, that is especially affected by normal ageing. It's our hippocampus that we use in searching for our car in a crowded parking lot. When we park, our brain, without prompting, will note spatial cues in the environment and keep them in mind to guide us back to the same place hours later. But the older we are, the more likely we are to forget those spatial cues, throw in the towel, and press the panic button to find the car. ''As we get older, we have fewer stem cells and newly born neurons in our brains, and our learning and memory are affected,'' says Villeda. ''It's not dementia, it's just the natural 
degeneration associated with age.''Flipping Switches: Clearly, the young blood helped turn back the clock for Villeda's old mice. So he began searching for molecular and biochemical changes in their brains that might explain the transformation. To accomplish this, he used the somewhat macabre technique of parabiosis, which involves sewing a young mouse to an old mouse so they share a single blood supply. After a month, he sequenced the genes of the old mice and found that the biggest changes occurred in genes associated with neuronal plasticity, the brain's response to learning. When we are learning or responding to our environment, our brain either increases the number of connections among neurons or strengthens our existing neuronal connections. ''Normally, with ageing, the activity of genes that control synaptic plasticity decreases,'' says Villeda. ''We saw that exposure to young blood increased the expression or activity of these genes.'' The old mice with the new high-octane blood were blazing through the mazes because their neurons were making new connections, and solidifying previous connections, with the vigour of mice less than half their age. Villeda and his students searched the gene array for some sort of mechanism that might be responsible for the surge of neuroplasticity in these middle-aged mice who, without the blood infusion, might still be trapped in the maze. The patterns of activated genes and changes they found looked to Villeda like the work of a master regulator known as CREB. ''CREB is an old friend of neuroscience,'' he explains. ''We know that it's very important for learning and memory, especially during development.'' To figure out the extent of CREB's role, a student in Villeda's lab manufactured a virus carrying a phosphate that would turn CREB off, then repeated the blood-infusion experiments on mice lacking this master regulator. In the new experiments, the old mice with young blood gained some benefits of youth, but the effect was significantly dampened. The experiments showed clearly that CREB is important – but that it doesn't work alone. ''Now we know that as we get older, we are not necessarily losing the genes or proteins in our brains that we need to improve cognition. Maybe, like CREB, they are just not as active,'' says Villeda. ''We've identified one part of the mechanism to wake up the brain. Now we have to find the other genes it works with to replicate the full effect.'' Hold or Reset? Villeda is quite excited at the prospect of applying these findings to humans – a sentiment surely shared by anyone over the age of 40. ''We know rejuvenation exists,'' he says. ''Now we have to figure out the bare minimum of therapeutics or genetic tinkering necessary for it to be safely translated into a human. There are so many questions we have yet to answer.'' For example: What part of plasma is really driving the changes, and are they lasting? Mice only live an average of three years; we live 80. How often would humans have to be treated, and when should treatments start? Cell proliferation slows in old age, perhaps to offset cancer risk. Would young blood factors stimulate cancer? If so, it might be more prudent to switch off the mechanisms that initiate the ageing cascade. ''People who have a genetic predisposition for Alzheimer's have a mutation, but they don't get the effects until later in life, which means that something in their young bodies knew how to fight it or compensate for it,'' says Villeda. ''If we could reverse some of the ageing signs, perhaps we could maintain ourselves at a younger stage and then maybe not have to deal with diseases until far later in life.'' Game On: While Villeda is turning back the clock in his cohort of mice, Adam Gazzaley, MD, PhD, is beating back cognitive decline with a joystick. Dressed in a black shirt and sleek gray blazer, Gazzaley looks more like a biotech executive than a neuroscientist. It turns out he's both. Gazzaley rocked the world of neuroscience last fall with the release of a video game, NeuroRacer, that dramatically improved cognitive performance in elderly players. In the game, players drive a car along a winding track, while various signs flash into view along the way. Players are instructed to press a button when a specific sign pops up, ignoring the rest, all while keeping their eyes on the road. ''We developed NeuroRacer to put pressure on cognitive control abilities in a powerful way in older adults, who we know have deficits in this domain just by virtue of their age,'' says Gazzaley. ''The results were better than we even dreamed of.'' After one month and just 12 hours of training, players who were between 60 and 85 years old were scoring as well as 20-somethings who had just learned the game. And, retested six months later, the players were still holding onto those gains. The cognitive skills Gazzaley aimed to improve with his game are selective attention, sustained attention, working memory, and task switching. ''We are building a tool to help people develop the cognitive control skills they need to interact with their environment based on their goals,'' says Gazzaley. ''If we're trying to do too many things at once and can't hold our attention to something we want to focus on, then all aspects of our lives suffer, whether it is family, work, safety, or even entertainment.'' Using EEGs, Gazzaley was able to show increased brain activity in the prefrontal cortex of the older players. After they played the game, their EEGs started to resemble those of 20-somethings. The prefrontal cortex, considered the seat of cognitive control, is the last part of our brains to develop – at around age 25. It is also the area that distinguishes humans from all other species. The EEGs showed signs of connectivity to other parts of the brain as well. Like Villeda's mice and Nottebohm's canaries, Gazzaley's game-players were enhancing their neuroplasticity, adding new connections while strengthening existing ones. He confirmed these gains by testing other areas of cognition. When assigned a facial recognition challenge, Gazzaley's players showed improvements in working memory. This showed that the benefits of game play were transferable to other brain functions. Transfer, considered the gold standard for effectiveness in the field, is evidence of underlying neural connections among different areas of cognition. ''That's exactly what we wanted to achieve – to see if we could change the brain in a meaningful way,'' says Gazzaley, ''and have that accompanied by changes in cognitive abilities that we weren't directly targeting.'' NeuroRacer is clearly not your ordinary video game, in which users try to reach ever-higher levels of expertise. While popular first-person shooter games have been shown to improve cognitive abilities in young adults, Gazzaley says this happens by accident. NeuroRacer is a closed-loop game, in which the level of play is adjusted to the player's behavior – and eventually to his or her own brain. The next version of the game, which Gazzaley is developing with Boston-based Akili Interactive Labs, where he is chief science adviser, will feature closed loops that adapt during every second of play. Gazzaley's lab is also working on new games that employ transcranial electrical stimulation, a very mild shock targeted to particular parts of the brain to enhance learning. When playing one of these new games, the player receives low-frequency bursts of energy in certain parts of the frontal lobe. ''We are studying if you learn faster if you play a game while we stimulate you at the right frequency,'' Gazzaley explains. The therapeutic and educational potential of such games is real and vast. They could be targeted, like NeuroRacer, to a healthy elderly population or be used as an educational tool in schools. Or they could be used to ameliorate known deficits in old and young alike. Gazzaley is currently working with pediatric neurologist Elysa Marco, PhD, on a game aimed at helping children with attention deficit disorder to better train their focus. The two are also teaming up to develop games for patients with autism, in an effort to stimulate the parts of their brains that the disorder has locked away. 
80 IS THE NEW 20: The brain's command center for multitasking is in the prefrontal cortex. The brain scan on the left depicts the prefrontal cortex activity of Gazzaley's 20-year-old subjects as they played NeuroRacer, a video game that involves multitasking. The scan in the middle depicts the starting point for his 60- to 85-year-old players, playing the game the first time. And the scan on the right shows the progress the older players made after playing a total of just 12 hours over the course of a month. Their scans showed signatures of brain activity comparable to that of the 20-year-olds who had played the game once. New blood: Gazzaley and Villeda come at cognition along very different paths, but with equally impressive vigor and results. And they are energised by each other's work. ''Adam's games are incredible,'' says Villeda. ''Soon we will be able to grab an iPad and do games that will significantly improve our cognition. Who would have thought of that?'' Villeda sees parallels in their approaches to enhancing cognition during the ageing process – through collaboration. He joined forces with bioinformaticians to help him sort through his data, with molecular biologists to create viruses, and with behavioural neuroscientists to identify the best ways to test cognition. ''Immunology, neurobiology, and stem cell science all come together when talking about rejuvenation,'' says Villeda. He believes that building bridges among disciplines will be critical for translating what is now fascinating research into the clinical realm. ''Saul's and my research could be very synergistic in ways that we don't fully understand right now, and Alvarez-Buylla's work has been foundational to neuroscience,'' says Gazzaley. ''There is no Holy Grail for enhancing cognition, so what we probably should have been focusing on for the past 40 years is how the many interventions in our toolbox might interact with each other.'' Perhaps someday soon, baby boomers will be able to relive their 20s, at least cognitively, by taking a shot of Villeda's revitalizing plasma while playing a video game developed by Gazzaley. Or maybe Alvarez-Buylla will have figured out how to engineer the perfect mix of neural stem cells to rebuild what age tears down. While we wait, Gazzaley urges us to apply all the strategies that science has already endorsed: Research has long shown that diet, exercise, and enriched, engaging environments are good for the brain. In fact, a new study out of the Cleveland Clinic showed that people with a genetic predisposition for Alzheimer's were able to stave off neurologic decline with a three-day-a-week exercise routine. Those with the same disposition who chose not to get off the couch showed significant degeneration. ''Clearly the brain does not do well with comfort,'' Gazzaley says, ''so challenge it as much as you can.'' Source: domain-b.com, Image: flickr.com
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